Why is it Important to Research Rare Cannabinoids?

Everywhere you look, there seems to be an article highlighting the newest benefit of cannabinoids. We know they can better human lives, so why do we need to research rare cannabinoids?

In actuality, there isn’t a lot of rigorous scientific research on this class of compounds. Much of the “new” information posted online is creatively using one of the few existing studies to support a new claim.

We need more specific testing to demonstrate how these compounds affect each organ, including skin, for indications. Then, this data should be retested to verify the results.

In other words, more rigorous science is needed to explore these rare bioactives.

Part of the issue is that, historically, due to regulations and availability, these compounds were not accessible to researchers. Federal changes in how hemp is classified opened the door for more research but securing the quantities of these ingredients needed is still difficult.

Companies like Demetrix are solving this issue by making rare cannabinoids through biotechnology, providing researchers with large volumes of highly pure, sustainably produced compounds.

Thanks to greater availability of highly pure cannabinoids, research has been expanding in the past years.

This is good news for consumers who deserve products that are safe and efficacious.

Now that we have access to rare bioactives to study, how do we test them for efficacy?


Types of Assays to Study Cannabinoids

There are several types of assays that can be used: in vitro, ex vivo, and in vivo.

In vitro assays can include putting the cannabinoid in a test tube with certain ingredients and then reading an outcome to see what happens. Another type of in vitro assays uses cell lines that are grown in Petri dishes. The cells can be treated to stimulate a certain pathway, then treated with compound to see how it affects the process.

Ex vivo assays use tissues outside the body. For example, skin from plastic surgery operations is treated and shipped to a research facility. This allows scientists to determine how an ingredient reacts with all layers of skin.

In vivo studies are generally clinical trials. Participants in a study will have baseline measurements taken, then use a product for a certain amount of time and have the measurements redone. Examples include testing skin hydration levels, or pigmentation.

There are great 3D imaging tools to look deep within the skin without being invasive.

How do You Know Which Assay to Do?

We generally start with in vitro assays to determine if there is a benefit. If we see a good result, we may opt to do additional in vitro assays to confirm the result or move to ex vivo.

The process of determining if an ingredient provides the desired result takes time. We want to ensure it is safe, and that there is strong indication it will provide a benefit before allowing humans to test a product.

What’s Next?

At Demetrix, we are dedicated to identifying rare bioactive compounds and developing those with proven efficacy. We believe in providing access to these rare ingredients and performing research to understand the unique benefits of each.

We are both conducting and enabling research to understand the benefits of these ingredients for human health and wellness.



Rare Access: Winning Strains in High Throughput Screening

Read More
Amber bottles with white labels on table

Market Applications for Rare Bioactives

Read More

Rare Access: Facilities Team & Recent Building Expansion

Read More
Back view of woman washing her hair

Can CBG Fight Dandruff?

Read More

Rare Access: High Throughput Process Engineering

Read More

Why is it Important to Research Rare Cannabinoids?

Read More